We are seeking highly motivated students to undertake a laboratory experimental study for Master Thesis (LM) in Biotechnology.
Possibility to start in September -December 2024.
Project Title: Study of the mechanism of action drugs promoting remyelination in cellular models.
Remyelination is the natural process that restores the myelin of damaged axons in the adult brain. Myelin can be disrupted during life as a consequence of injury, viral infection or disease progression. Remyelination can restore saltatory current and thereby neuronal function. Unfortunately, remyelination is incomplete as a consequence of disease progression or ageing. Cumulating data suggest that pharmacological intervention can be used to restore the ability of neural stem cells to mature into myelinating Ols. We previously selected some promising drugs that need to be studied to clarify their molecular mechanism of action (Al Jaf et al., Cells 2024). Understanding how remyelination occurs in adult CNS in normal and pathological conditions will open new avenues for the possibility of treating neurodegenerative diseases among which are Multiple Sclerosis, Alzheimer’s, Parkinson and ageing-related dementia. Drug screening, HTS imaging and analyses, qPCR and CRISP-CAS9 KO and Knock-in are among the methodologies that you will learn during the thesis.
For position enquire please e-mail to: antonella.ragnini@uniroma2.it
