Neuroscience

Laboratory Antonella Ragnini-Wilson, Ed PP1 second Floor AA 2026/2027
We are looking for 2 motivated students interested in an experimental thesis focused on the mechanism of regeneration of the myelin sheath for Multiple Sclerosis remyelination therapies Loss of myelin is a hallmark of several debilitating neurological disorders, including multiple sclerosis, leukodystrophies, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and frontotemporal dementia. Our group uses phenotypic screening and AI-based virtula screen combined with biochemical and genetic tools, to identify and validate pro-myelinating compounds that promote myelin repair and thereby nerve functional recovery. The thesis project will focus on validating recently identified compounds in human iPSC-derived OPCs and investigating their molecular targets and mechanisms of action in Oli-neuM mouse oligodendroglial cell lines. Students will receive hands-on training in modern experimental techniques, including cell culture, immunostaining and immunoblotting, high-content microscopy, RT-PCR, CRISPR/Cas9 genome editing, gene silencing, and transcriptomic analysis. This project offers a valuable opportunity to gain experience in translational neuroscience research with direct relevance to human disease. The duration of the experimental project is 1 year. Students at the end of the first year of their Master’s course are encouraged to apply For information and application, please contact: Antonella.Ragnini@uniroma2.eu, with the object experimental thesis request